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Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release
| Title | Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Soares PIP a, Sousa AI a, Ferreira IMM a, Novo CMM b, Borges JP a |
| Journal | Carbohydrate Polymers |
| Volume | 153 |
| Pagination | 212-221 |
| ISSN | 01448617 |
| Keywords | Chitin, Chitosan, Composite materials, Composite nanoparticles, Doxorubicin, Drug delivery, Drug delivery system, Hydrodynamic diameter, Iron, Iron oxide nanoparticle, Iron oxides, Mathematical models, Metal nanoparticles, Nanomagnetics, Nanometric ranges, Nanoparticles, Polymeric nanoparticles, Release mechanism, Synthesis (chemical) |
| Abstract | In the present work composite nanoparticles with a magnetic core and a chitosan-based shell were produced as drug delivery systems for doxorubicin (DOX). The results show that composite nanoparticles with a hydrodynamic diameter within the nanometric range are able to encapsulate more DOX than polymeric nanoparticles alone corresponding also to a higher drug release. Moreover the synthesis method of the iron oxide nanoparticles influences the total amount of DOX released and a high content of iron oxide nanoparticles inhibits DOX release. The modelling of the experimental results revealed a release mechanism dominated by Fickian diffusion. © 2016 Elsevier Ltd |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979951018&doi=10.1016%2fj.carbpol.2016.07.109&partnerID=40&md5=193d8340f3a053838eb9da37b92d42dc |
| DOI | 10.1016/j.carbpol.2016.07.109 |
